Transcription

PPAR Gamma transcription factor    |    Biointeractive.org, Eric Keller, HHMI

Shows fat cells in the adipose tissue adjacent to muscle – storage / breakdown of the cell’s fat droplet affects the balance of secreted adiponectin and resistin hormones. The effect of drugs against PPAR gamma is also shown to affect this balance and resulting insulin sensitivity.

» View the animation at HHMI

PPAR Delta transcription factor    |    Biointeractive.org, Eric Keller, HHMI

Shows the effects of drug-binding to the PPAR-delta transcription factor receptor on DNA – a repressor is released thereby turning on the muscle delta network on genes. Oxidative metabolism is activated and leads to reduction of fat pads in adipose tissue.

» View the animation at HHMI

p53 transcription factor    |    Biointeractive.org, Eric Keller, HHMI

This animation highlights the structure of p53 protein and its binding to a cognate promoter. Recruitment of RNA polymerase and transcription are also shown.

» View the animation at HHMI

MECP2 transcription factor    |    Biointeractive.org, Eric Keller, HHMI

This animation show the effects of MECP2 DNA methylation (CpG islands) on recruitment of Sina3/HDAC, nuclesome modification and gene silencing.

» View the animation at HHMI

DNA Central Dogma Part 1 – Transcription    |    Drew Berry

Transcription factors assemble at a DNA promoter region found at the start of a gene. Promoter regions are characterised by the DNA’s base sequence, which contains the repetition TATATA É and for this reason is known as the “TATA box”.

» View the animation at WEHI