HHMI

PPAR Gamma transcription factor    |    Biointeractive.org, Eric Keller, HHMI

Shows fat cells in the adipose tissue adjacent to muscle – storage / breakdown of the cell’s fat droplet affects the balance of secreted adiponectin and resistin hormones. The effect of drugs against PPAR gamma is also shown to affect this balance and resulting insulin sensitivity.

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PPAR Delta transcription factor    |    Biointeractive.org, Eric Keller, HHMI

Shows the effects of drug-binding to the PPAR-delta transcription factor receptor on DNA – a repressor is released thereby turning on the muscle delta network on genes. Oxidative metabolism is activated and leads to reduction of fat pads in adipose tissue.

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p53 transcription factor    |    Biointeractive.org, Eric Keller, HHMI

This animation highlights the structure of p53 protein and its binding to a cognate promoter. Recruitment of RNA polymerase and transcription are also shown.

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MECP2 transcription factor    |    Biointeractive.org, Eric Keller, HHMI

This animation show the effects of MECP2 DNA methylation (CpG islands) on recruitment of Sina3/HDAC, nuclesome modification and gene silencing.

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RNA Folding    |    Biointeractive.org, HHMI

A short animated sequence showing how RNA can fold back onto itself (through the formation of intramolecular base-pairing).

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Tri Nucleotide Repeat    |    Biointeractive.org, Drew Berry, HHMI

This animation shows how a tri-nucletoide repeat can cause the DNA polymerase to ‘slip’ and incorporate additional nucleotides during the replication process.

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Proteasome & Ataxin    |    Biointeractive.org, Eric Keller, HHMI

This Maya animation depicts the process of ubiquitin-dependent degradation in the proteasome. The effect of mutant ataxin no this process is also shown.

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Embryonic Germ Layers    |    Biointeractive.org, Blake Porch, HHMI

This animation briefly summarizes the early stages of development and highlights/maps the organ systems in the adult that result from the 3 embryonic germ layers.

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Embryonic Development    |    Biointeractive.org, Blake Porch, HHMI

Covers the early stages of embyronic development (including fertilization, cleavage, blastocyst formation, implantation, cell migration in the inner cell mass and formation of the embryo’s germ layers and neural tube formation).

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